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Tapentadol is a centrally acting opioid analgesic used to manage moderate to severe pain. It was developed as an alternative to other opioids like morphine, oxycodone, and tramadol. Tapentadol works by binding to opioid receptors in the brain and spinal cord, thus altering the perception of pain. One unique aspect of tapentadol is its dual mechanism of action. In addition to its opioid activity, it also has norepinephrine reuptake inhibition properties. This means that it can help enhance the body’s natural pain-relieving mechanisms by increasing the levels of norepinephrine, a neurotransmitter that plays a role in pain modulation.
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